DNA (cytosine-5)-methyltransferase 3B (IPR030488)

Short name: DNMT3B

Family relationships


In mammals, DNA methylation patterns are thought to be established during embryonic development by de novo DNA methyltransferases 3A and 3B (DNMT3A/3B) [PMID: 10555141]. This entry represents DNMT3B. DNMT3A/3B work synergistically to propagate methylation patterns with DNMT3B stimulating DNMT3A activity by promoting its association with nucleosomes [PMID: 21304883]. Many DNMT3B isoforms from alternative splicing have been described, among which DNMT3B3 stimulates the basal activity of DNMT3 enzymes, but partially inhibits the stimulatory effect of DNMT3L, whereas DNMT3B4 significantly impairs de novo methylation [PMID: 25198254, PMID: 23894490]. DNMT3B is involved in development and is associated with several diseases, including cancers [PMID: 25198254].

GO terms

Biological Process

GO:0006306 DNA methylation
GO:0010468 regulation of gene expression

Molecular Function

GO:0009008 DNA-methyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.