DNA (cytosine-5)-methyltransferase 3A (IPR030487)

Short name: DNMT3A

Overlapping homologous superfamilies


Family relationships


In mammals, DNA methylation patterns are thought to be established during embryonic development by de novo DNA methyltransferases 3A and 3B (DNMT3A/3B) [PMID: 10555141]. DNMT3A/3B work synergistically to propagate methylation patterns with DNMT3B stimulating DNMT3A activity by promoting its association with nucleosomes [PMID: 21304883]. DNMT3A exists in an autoinhibitory form that can be activated by the histone H3 tail in a DNMT3L-independent manner [PMID: 25383530]. DNMT3A has been linked to cancers [PMID: 25416277, PMID: 25416276, PMID: 25358520].

GO terms

Biological Process

GO:0006306 DNA methylation
GO:0010468 regulation of gene expression

Molecular Function

GO:0009008 DNA-methyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.