Family

Lysosomal-trafficking regulator (IPR030464)

Short name: LYST

Family relationships

None.

Description

Lysosomal-trafficking regulator (LYST) is a large BEACH domain-containing protein that affects lysosome size and quantity [PMID: 25216107]. LYST controls the terminal maturation of perforin-containing vesicles into secretory granules [PMID: 25425525]. Mutations in the LYST gene causes Chediak-Higashi syndrome, which is a rare autosomal-recessive syndrome characterised by hypopigmentation, severe immune deficiency, a bleeding tendency and progressive neurological dysfunction [PMID: 8717042, PMID: 24521565].

GO terms

Biological Process

GO:0007040 lysosome organization

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER