Stromal interaction molecule 1 (IPR030463)

Short name: STM1

Overlapping homologous superfamilies


Family relationships


Stromal interaction molecule 1 (STM1) is a single-pass transmembrane protein that spans the ER membrane, with its N-terminal region (STIM1-N, approximately 22 kDa) located in the ER lumen [PMID: 22451904, PMID: 24069340]. Upon store depletion, it serves as a Ca2+ sensor that activates Orai1, a CRAC (calcium-release-activated calcium) channel in the plasma membrane [PMID: 16208375, PMID: 18854159]. CRAC channel is a store-operated calcium (SOC) influx channel that is important in Ca2+ signalling and many other cellular processes [PMID: 16208375].

GO terms

Biological Process

GO:0032237 activation of store-operated calcium channel activity
GO:0051924 regulation of calcium ion transport

Molecular Function

GO:0005246 calcium channel regulator activity

Cellular Component

GO:0030176 integral component of endoplasmic reticulum membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.