Junction plakoglobin/protein humpback-2 (IPR030461)

Short name: Plakoglobin/HMP-2

Overlapping homologous superfamilies

Family relationships

  • Beta-catenin (IPR013284)
    • Junction plakoglobin/protein humpback-2 (IPR030461)


This entry includes plakoglobin from vertebrates and protein humpback-2 from C. elegans.

Plakoglobin is an armadillo repeat protein found in adherens junctions, where it interacts with the cytoplasmic domain of classical cadherins and with alpha-catenin. It is also a structural constituent of desmosomes, where it binds to the cytoplasmic domains of the desmosomal cadherins, desmogleins and desmocollins [PMID: 19759396]. It acts as a substrate for vascular endothelial protein tyrosine phosphatase (VE-PTP) and is required by it to stimulate vascular endothelial (VE)-cadherin function in endothelial cells. It can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton [PMID: 19015309]. Plakoglobin has multiple functions as a a cell adhesion molecule and may also have a role as transcriptional activator in Wnt signalling [PMID: 10954412, PMID: 14661054].

C. elegans protein humpback-2 (HMP-2) is a beta-catenin involved in cell adhesion. It also functions downstream of Src in parallel with the Wnt pathway in early embryogenesis [PMID: 21575624].

GO terms

Biological Process

GO:0007155 cell adhesion
GO:0002159 desmosome assembly

Molecular Function

GO:0045294 alpha-catenin binding
GO:0045296 cadherin binding
GO:0005198 structural molecule activity

Cellular Component

GO:0016342 catenin complex
GO:0005913 cell-cell adherens junction

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.