Envoplakin (IPR030460)

Short name: Envoplakin

Overlapping homologous superfamilies


Family relationships



Envoplakin belongs to the plakin family of cytolinker proteins, which also includes desmoplakin, plectin, periplakin and BPAG1 (bullous pemphigoid antigen) [PMID: 12432088]. It was originally identified as components of the cornified envelope (CE) [PMID: 6200236, PMID: 8707850]. It is also found in the desmosomes of keratinocytes and other epithelial cells [PMID: 12432088]. Envoplakin and periplakin can form stable heterodimers that localise to desmosomes and the plasma membrane in a manner dependent on the periplakin N terminus [PMID: 18166659]. The C termini of envoplakin and periplakin bind intermediate filaments, and this interaction may provide the link between the cytoskeleton and the CE that confers mechanical stability to corneocytes [PMID: 12432088, PMID: 18166659].

GO terms

Biological Process

GO:0008544 epidermis development

Molecular Function

GO:0019215 intermediate filament binding
GO:0005198 structural molecule activity

Cellular Component

GO:0001533 cornified envelope

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.