Histone H3-K79 methyltransferase (IPR030445)

Short name: H3-K79_meTrfase

Overlapping homologous superfamilies


Family relationships


The enzymes that catalyse histone methylation are classified into 3 families: the PRMT (protein arginine N-methyltransferase) family, the SET-domain-containing family, and the non-SET domain proteins. Lysine 79 (K79) of H3 is methylated by a methyltransferase represented in this entry that lacks a SET domain [PMID: 22473383].

H3K79 methylation occurs in a variety of organisms ranging from yeast to human. In budding yeast, K79 methylation is mediated by the silencing protein Dot1 [PMID: 12080090]. Dot1 homologues can be found in a variety of eukaryotic organisms; in mammals the homologous protein is called Dot1-like protein (DOT1L) [PMID: 12123582, PMID: 14572310]. Dot1/DOT1L catalyses the sequential mono-, di-, and tri-methylation of H3K79, while SET domain-containing methyltransferases mediate methylation in a processive manner [PMID: 18511943]. K79 methylation level is regulated throughout the cell cycle and plays a critical role in the progression of G1 phase, S phase, mitosis, and meiosis [PMID: 24526115].

GO terms

Biological Process

GO:0034729 histone H3-K79 methylation
GO:0051726 regulation of cell cycle

Molecular Function

GO:0031151 histone methyltransferase activity (H3-K79 specific)

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.