Liprin-alpha-2 (IPR030441)

Short name: PPFIA2

Family relationships


Liprin-alpha-2 is a member of the LAR (leukocyte common antigen-related) protein tyrosine phosphatase-interacting protein (liprin) family [PMID: 9624153]. Liprin-alpha family proteins in mammals are expressed at high levels in the brain and are engaged in high-affinity interactions with many presynaptic active zone proteins [PMID: 17956329]. Liprin-alpha-2 is one of the predominant Liprin isoforms in the hippocampus [PMID: 21618222, PMID: 21618221]. It organises presynaptic ultrastructure and controls synaptic output by regulating the synaptic vesicles pool size [PMID: 23751498].

Liprin was originally identified as binding partners of the receptor protein tyrosine phosphatase LAR (leukocyte common antigen-related), which functions in axon guidance and mammary gland development [PMID: 9624153]. In vertebrates, there are two families of liprins, liprin-alpha and liprin-beta, which have four (alpha1-4) and two (beta1-2) members. Liprins contain an N-terminal coiled-coil domain and a C-terminal liprin homology (LH) region comprised of three sterile alpha motif (SAM) domains. The N-terminal coiled coils of liprin-alpha act as binding regions for several synaptic protein, while the SAM repeats can bind to both phosphatases and protein kinases [PMID: 21855798]. The autophosphorylation of liprin regulates its association with LAR [PMID: 16313174]. Interestingly, all Liprin-alpha genes are subject to alternative splicing, which is regulated in a developmental manner [PMID: 19013515]. The structure of the human CASK/liprin-alpha/liprin-beta ternary complex has been revealed [PMID: 21855798].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0045202 synapse

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.