Pathways & interactions
Cleft lip and palate transmembrane protein 1-like protein (IPR030434)
Short name: CLPTM1L
Overlapping homologous superfamilies
- Cleft lip and palate transmembrane 1 (IPR008429)
- Cleft lip and palate transmembrane protein 1-like protein (IPR030434)
Cleft lip and palate transmembrane protein 1-like protein (CLPTM1L), also known as CRR9 (cisplatin resistance-related protein 9), is a transmembrane protein overexpressed in non-small cell lung cancer, where it protects tumour cells from genotoxic apoptosis [PMID: 24366883]. It has been identified as an overexpressed protein in human ovarian tumour cell lines that are resistant to cisplatin [PMID: 22675468]. CLPTM1L may protect cells from genotoxic stress induced apoptosis through regulation of Bcl-xL [PMID: 22675468]. It interacts with phosphoinositide 3-kinase and is essential for Ras-induced AKT phosphorylation [PMID: 24366883]. The CLPTM1L gene lies within a cancer susceptibility locus at chromosome 5p15.33 (TERT-CLPTM1L) defined by genome-wide association studies [PMID: 24366883].
- PTHR21347:SF0 (PTHR21347:SF0)