Cleft lip and palate transmembrane protein 1-like protein (IPR030434)

Short name: CLPTM1L

Overlapping homologous superfamilies


Family relationships


Cleft lip and palate transmembrane protein 1-like protein (CLPTM1L), also known as CRR9 (cisplatin resistance-related protein 9), is a transmembrane protein overexpressed in non-small cell lung cancer, where it protects tumour cells from genotoxic apoptosis [PMID: 24366883]. It has been identified as an overexpressed protein in human ovarian tumour cell lines that are resistant to cisplatin [PMID: 22675468]. CLPTM1L may protect cells from genotoxic stress induced apoptosis through regulation of Bcl-xL [PMID: 22675468]. It interacts with phosphoinositide 3-kinase and is essential for Ras-induced AKT phosphorylation [PMID: 24366883]. The CLPTM1L gene lies within a cancer susceptibility locus at chromosome 5p15.33 (TERT-CLPTM1L) defined by genome-wide association studies [PMID: 24366883].

GO terms

Biological Process

GO:0006915 apoptotic process

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.