Membrane-spanning 4-domains subfamily A member 6A/6E (IPR030427)

Short name: MS4A6A/MS4A6E

Overlapping homologous superfamilies


Family relationships


MS4A6A and MS4A6E are members of the membrane-spanning 4-domains family A (MS4A). MS4A6E and MS4A6A genes appear to represent a recent duplication event, although several exons encoding translated sequence have been lost in the MS4A6E gene [PMID: 11486273]. They both have variants associated with Alzheimer's disease [PMID: 21460840, PMID: 24064185, PMID: 23226438, PMID: 23360175].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.