High affinity immunoglobulin epsilon receptor subunit beta (IPR030420)

Short name: MS4A2

Overlapping homologous superfamilies


Family relationships


The high affinity immunoglobulin epsilon (IgE) receptor (FceRI) binds to the Fc region of IgE. A typical FceRI is a tetrameric hetero-oligomer composed of an alpha chain, a beta chain, and two disulfide-linked gamma chains [PMID: 1535625]. Interestingly, human monocytes, dendritic cells and Langerhans cells express FceRI without the beta subunit, employing an alphagamma2 FceRI trimeric receptor for antigen presentation [PMID: 22623922]. It has been suggested that the inclusion of beta in the FceRI produces a powerful inflammatory IgE-binding tetramer restricted to mast cells and basophils, and this plays an important role in IgE-mediated allergic reaction [PMID: 24447079].

This entry represents the subunit beta of the high affinity immunoglobulin epsilon (IgE) receptor (FceRI), also known as membrane-spanning 4-domains subfamily A member 2 (MS4A2). A coding variant of MS4A2 has been associated with asthma [PMID: 8817330, PMID: 8842731].

GO terms

Biological Process

GO:0038095 Fc-epsilon receptor signaling pathway
GO:0006954 inflammatory response

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0032998 Fc-epsilon receptor I complex
GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.