B-lymphocyte antigen CD20 (IPR030418)

Short name: MS4A1

Overlapping homologous superfamilies


Family relationships


CD20, also known as membrane-spanning 4-domains subfamily A member 1 (MS4A1), was the first B cell differentiation antigen identified. CD20 is highly expressed by B cell lymphocytes throughout their development, but is absent on the hematopoietic stem cells [PMID: 6157744]. Anti-CDC20 antibodies are commonly used for the treatment of B-cell lymphoid malignancies [PMID: 21090841].

The function of CD20 remains unclear. It may be involved in calcium signalling downstream of B cell antigen receptor activation [PMID: 18426802, PMID: 18474602]. CD20 has a been shown to play a central role in the generation of T cell-independent antibody responses [PMID: 20038800].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.