Membrane-spanning 4-domains subfamily A (IPR030417)

Short name: MS4A

Overlapping homologous superfamilies


Family relationships


Membrane-spanning four-domains subfamily A (MS4A) includes B-cell-specific antigen CD20 (MS4A1), high affinity immunoglobulin epsilon receptor beta chain (MS4A2), hematopoietic-cell-specific protein HTm4 (MS4A3), and related proteins. These proteins share a similar structure with four transmembrane domains and have amino acid identities of 25-40% [PMID: 11245982]. They are predominantly expressed in hematopoietic cells, but some can be found in other tissues including testis and brain [PMID: 11162526, PMID: 11401424].

MS4A1 (B-lymphocyte antigen CD20) [PMID: 20038800], MS4A2 (high affinity IgE receptor subunit beta) [PMID: 16272347, PMID: 19001085], and MS4A4B [PMID: 19752228] have been shown to have an important role in immunity.

Several variants within the MS4A gene cluster have been implicated in Alzheimer's disease [PMID: 24981432].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.