Evi1/Prdm16 (IPR030413)

Short name: Evi1/Prdm16

Family relationships



Protein Hamlet (Ham) is a key target of the SWI/SNF complex (a nucleosome remodeling complex) in Drosophila [PMID: 24630726]. It has critical roles in cell fate decisions in external sensory organs and the olfactory system [PMID: 12193790, PMID: 15075290, PMID: 22197833]. Hamlet is the Drosophila homologue of Prdm3/Evi1 and Prdm16, two mammalian proteins that can act as proto-oncogenes and tumour suppressors [PMID: 22028065, PMID: 22669819]. Evi1 and Prdm16 act redundantly in initiating heterochromatin formation in mammals [PMID: 22939622].

Evi1 (Ecotropic viral integration site-1, also known as MECOM), is one of the dominant oncogenes associated with murine and human myeloid leukemia [PMID: 20532840]. Evi1 contains several zincfinger motifs, which are grouped into the first zinc-finger domain (ZF1) and the second zinc-finger domain (ZF2). ZF1 is required for its interaction with transcriptional regulator Smad3 and protein kinase JNK1 [PMID: 9665135, PMID: 10856240].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.