Family

Evi1/Prdm16 (IPR030413)

Short name: Evi1/Prdm16

Family relationships

None.

Description

Protein Hamlet (Ham) is a key target of the SWI/SNF complex (a nucleosome remodeling complex) in Drosophila [PMID: 24630726]. It has critical roles in cell fate decisions in external sensory organs and the olfactory system [PMID: 12193790, PMID: 15075290, PMID: 22197833]. Hamlet is the Drosophila homologue of Prdm3/Evi1 and Prdm16, two mammalian proteins that can act as proto-oncogenes and tumour suppressors [PMID: 22028065, PMID: 22669819]. Evi1 and Prdm16 act redundantly in initiating heterochromatin formation in mammals [PMID: 22939622]. This entry also includes oocyte zinc finger protein XlCOF29 from Xenopus.

Evi1 (Ecotropic viral integration site-1, also known as MECOM), is one of the dominant oncogenes associated with murine and human myeloid leukemia [PMID: 20532840]. Evi1 contains several zincfinger motifs, which are grouped into the first zinc-finger domain (ZF1) and the second zinc-finger domain (ZF2). ZF1 is required for its interaction with transcriptional regulator Smad3 and protein kinase JNK1 [PMID: 9665135, PMID: 10856240].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER