Phosphatidylinositol-binding clathrin assembly protein (IPR030412)

Short name: PICALM

Overlapping homologous superfamilies


Family relationships



PICALM (also known as clathrin assembly lymphoid myeloid leukemia protein, CALM) is a phosphatidylinositol-binding clathrin assembly protein that plays important roles in clathrin-mediated endocytosis in all cell types [PMID: 23589030, PMID: 22639918]. It modulates autophagy activity and tau accumulation, thus may influence the severity of Alzheimer's disease (AD) [PMID: 25241929, PMID: 25186232]. PICALM is required for erythroid maturation and transferrin internalisation in mice [PMID: 22363754]. PICALM deficiency in mice results in impaired hematopoiesis, anemia, abnormal iron metabolism, growth defects, and shortened life span. It plays a key role in iron homeostasis and cell proliferation [PMID: 22952941].

GO terms

Biological Process

GO:0048268 clathrin coat assembly
GO:0006897 endocytosis

Molecular Function

GO:0005545 1-phosphatidylinositol binding

Cellular Component

GO:0030136 clathrin-coated vesicle

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.