Protein strawberry notch homologue 2 (IPR030410)

Short name: SBNO2

Overlapping homologous superfamilies


Family relationships


This entry represents the protein strawberry notch homologue 2 (SBNO2) from vertebrates. It may be a component of the pathways that contribute to the downstream anti-inflammatory effects of IL-10 [PMID: 18025162]. The genetic variations in the SBNO2 gene have been linked to susceptibility to Crohn's disease, a type of inflammatory bowel disease (IBD) that may affect any part of the gastrointestinal tract from mouth to anus [PMID: 21351207].

Strawberry notch proteins carry DExD/H-box groups and helicase C-terminal domains. These proteins promote the expression of diverse targets, potentially through interactions with transcriptional activator or repressor complexes [PMID: 20230814]. Strawberry notch was first identified in Drosophila where functions downstream of Notch and regulates gene expression during development [PMID: 9171377, PMID: 12419199].

GO terms

Biological Process

GO:0050727 regulation of inflammatory response

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.