Disabled homologue 2-interacting protein (IPR030403)

Short name: DAB2IP

Overlapping homologous superfamilies

Family relationships


DAB-2 interacting protein (Dab2IP) is a GTPase activating protein involved in the regulation of multiple signalling pathways. Dab2IP regulates PI3K-AKT signalling and functions as a tumour suppressor. It modulates the balance between phosphatidylinositol 3-kinase (PI3K) mediated cell survival and ASK1 mediated apoptosis [PMID: 15310755, PMID: 19903888]. Besides its function as a tumour suppressor, Dab2IP is also highly expressed in the brain, where it interacts with Dab1 (Disabled homologue 1), a key mediator of the Reelin pathway that controls several aspects of brain development and function [PMID: 23056358, PMID: 12877983, PMID: 23326475]. It also functions as an inhibitor in VEGFR2-mediated adaptative angiogenesis [PMID: 19033661].

Dab2IP has been associated with metastatic prostate cancer [PMID: 18073375], abdominal aortic aneurysms [PMID: 20622881] and coronary heart disease [PMID: 21444365].

GO terms

Biological Process

GO:0016525 negative regulation of angiogenesis
GO:0008285 negative regulation of cell population proliferation
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0043065 positive regulation of apoptotic process
GO:0038026 reelin-mediated signaling pathway
GO:0043087 regulation of GTPase activity

Molecular Function

GO:0005096 GTPase activator activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.