Disabled homologue 2-interacting protein (IPR030403)
Short name: DAB2IP
Overlapping homologous superfamilies
- Rho GTPase activation protein (IPR008936)
- Ras GTPase-activating protein (IPR039360)
- Disabled homologue 2-interacting protein (IPR030403)
DAB-2 interacting protein (Dab2IP) is a GTPase activating protein involved in the regulation of multiple signalling pathways. Dab2IP regulates PI3K-AKT signalling and functions as a tumour suppressor. It modulates the balance between phosphatidylinositol 3-kinase (PI3K) mediated cell survival and ASK1 mediated apoptosis [PMID: 15310755, PMID: 19903888]. Besides its function as a tumour suppressor, Dab2IP is also highly expressed in the brain, where it interacts with Dab1 (Disabled homologue 1), a key mediator of the Reelin pathway that controls several aspects of brain development and function [PMID: 23056358, PMID: 12877983, PMID: 23326475]. It also functions as an inhibitor in VEGFR2-mediated adaptative angiogenesis [PMID: 19033661].
GO:0016525 negative regulation of angiogenesis
GO:0008285 negative regulation of cell population proliferation
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0043065 positive regulation of apoptotic process
GO:0038026 reelin-mediated signaling pathway
GO:0043087 regulation of GTPase activity
GO:0005096 GTPase activator activity
No terms assigned in this category.
- PTHR10194:SF26 (PTHR10194:SF26)