Domain

Era-type guanine nucleotide-binding (G) domain (IPR030388)

Short name: G_ERA_dom

Domain relationships

Description

Era (E. coli Ras-like protein) is a small G-protein widely conserved in eubacteria and eukaryotes. It is essential for bacterial cell viability and is required for the maturation of 16S rRNA and assembly of the 30S ribosomal subunit [PMID: 15866174]. Era couples cell growth with cytokinesis and plays a role in cell division and energy metabolism. Era contains an N-terminal GTPase domain and a C-terminal distinct derivative of the type-II RNA-binding KH domain [PMID: 11916378, PMID: 10852878, PMID: 19706445, PMID: 21646538]. Both domains are important for Era function. Era is functionally able to compensate for deletion of RbfA, a cold-shock adaptation protein that is required for efficient processing of the 16S rRNA.

The Era-type GTPase domain consists of a central six-stranded beta-sheet flanked by five alpha-helices, in which the GTP-binding site is located. Guanine nucleotide molecules interact with highly conserved G protein regions G1-G5 [PMID: 19706445].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005525 GTP binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
PROSITE profiles