SAM-dependent methyltransferase TRM5/TYW2-type (IPR030382)

Short name: MeTrfase_TRM5/TYW2

Overlapping homologous superfamilies

Domain relationships



This entry represents a domain found in the Trm5/Tyw2-type methyltransferase. Trm5 and Tyw2 are S-adenosylmethionine-dependent methyltransferases involved in tRNA methylation [PMID: 20382657].

Wybutosine synthesis is a multienzymatic process that comprises six sequential enzymatic reactions involving five enzymes. The initial step, the formation of m1G-37 (guanosine-37 methylated in the N1 position) in precursor tRNAPhe is catalysed by tRNA wybutosine-synthesising protein 5 (Trm5). Tyw2 catalyses the second step, consisting of the alpha-amino-alpha-carboxypropyl (acp) group being transferred from S-AdoMet to the side chain at the C7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86 [PMID: 16642040].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles