Family

ATP-binding cassette subfamily A member 7 (IPR030369)

Short name: ABCA7

Family relationships

  • ABC transporter A (IPR026082)
    • ATP-binding cassette subfamily A member 7 (IPR030369)

Description

ATP-binding cassette subfamily A member 7 (ABCA7) belongs to the ABC transporter family, whose remembers are full-length transporters organised in two tandem halves, each with a hydrophobic TMD followed by a cytoplasmic NBD [PMID: 23103747].

In macrophages, ABCA7 functions in phagocytosis and can be stabilised by HDL (high-density lipoprotein) apolipoproteins [PMID: 20495215]. ABCA7 has been linked to Alzheimer's disease pathogenesis [PMID: 24878767, PMID: 24908168]. It is also linked to Sjogrens syndrome, a chronic autoimmune disease characterised by the sicca symptoms of dry eyes and dry mouth [PMID: 12794264, PMID: 11355874].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER