Family

ATP-binding cassette subfamily A member 5 (IPR030367)

Short name: ABCA5

Overlapping homologous superfamilies

None.

Family relationships

  • ABC transporter A (IPR026082)
    • ATP-binding cassette subfamily A member 5 (IPR030367)

Description

ATP-binding cassette subfamily A member 5 (ABCA5) belongs to the ABC transporter family, whose remembers are full-length transporters organised in two tandem halves, each with a hydrophobic TMD followed by a cytoplasmic NBD [PMID: 23103747].

In mice, ABCA5 localises to lysosomes and late endosomes. It is linked to lysosomal disease [PMID: 15870284]. In humans, it may have a role in tumour development [PMID: 17541169]. ABCA5 in the brain seems to function as a cholesterol transporter associated with amyloid-beta peptides generation [PMID: 25125465].

GO terms

Biological Process

GO:0030301 cholesterol transport

Molecular Function

GO:0042626 ATPase activity, coupled to transmembrane movement of substances

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER