K/Cl co-transporter 3 (IPR030364)

Short name: KCC3

Overlapping homologous superfamilies


Family relationships


K+Cl- cotransporters (KCCs) belong to the SLC12 family and act as electroneutral symporters of K+ and Cl- ions across the plasma membrane [PMID: 6929518, PMID: 11125215]. They are major determinants of osmotic homeostasis. Four isoforms of KCC have been identified: KCC1, KCC2, KCC3, and KCC4. The four KCC isoforms share a common protein structure with a central core of twelve hydrophobic transmembrane domains [PMID: 10347194].

KCC3, also known as solute carrier family 12 member 6 (SLC12A6), mediates electroneutral potassium-chloride cotransport. In isotonic conditions, KCCs are inactive and phosphorylated, whereas hypotonicity and cell swelling promotes their dephosphorylation and activation. Several residues involved in regulation by phosphorylation have been identified in KCC3 [PMID: 24043619]. KCC3 has a role in proximal tubule glucose reabsorption in kidney [PMID: 24089410].

GO terms

Biological Process

GO:0071477 cellular hypotonic salinity response
GO:1902476 chloride transmembrane transport
GO:0006811 ion transport

Molecular Function

GO:0015379 potassium:chloride symporter activity

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.