Family

Phospholipid-transporting ATPase IG (IPR030363)

Short name: ATP11C

Family relationships

Description

Phospholipid-transporting ATPase IG (also known as ATP11C) belongs to subfamily IV of the P-type ATPases (P4-ATPase) family, whose members transport phospholipids across the membrane. ATP11C is ubiquitously expressed and binds CDC50A as its beta-subunit [PMID: 23103747].

In mice, ATP11C plays an important role in the proper development of B-cell lymphocytes [PMID: 21423173, PMID: 21423172, PMID: 24898253]. In human cells, ATP11C can function as a phosphatidylserine (PtdSer) flippase at the plasma membrane. During apoptosis, the inactivation of ATP11C is required for cells to expose and display apoptotic PtdSer, which then serves as an "eat me" signal for macrophages to engulf the cells [PMID: 24904167].

GO terms

Biological Process

GO:0045332 phospholipid translocation

Molecular Function

GO:0005524 ATP binding
GO:0004012 phospholipid-translocating ATPase activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER