K/Cl co-transporter 4 (IPR030354)

Short name: KCC4

Overlapping homologous superfamilies


Family relationships


K+Cl- cotransporters (KCCs) belong to the SLC12 family and act as electroneutral symporters of K+ and Cl- ions across the plasma membrane [PMID: 6929518, PMID: 11125215]. They are major determinants of osmotic homeostasis. Four isoforms of KCC have been identified: KCC1, KCC2, KCC3, and KCC4. The four KCC isoforms share a common protein structure with a central core of twelve hydrophobic transmembrane domains [PMID: 10347194].

KCC4, also known as solute carrier family 12 member 7 (SLC12A7), mediates electroneutral potassium-chloride cotransport when activated by cell swelling under hypotonic conditions [PMID: 10913127]. KCC4 has a role in salt reabsorption in the kidney [PMID: 24089410]. Furthermore, it functions as a membrane scaffold for the assembly of signalling complexes via the association with the actin-binding protein ezrin [PMID: 19887603]. It is upregulated by insulin-like growth factor 1 (IGF-1), and this interaction plays a role in IGF-1 receptor signalling promoting growth and spread of cancer cells [PMID: 17133354].

GO terms

Biological Process

GO:0006884 cell volume homeostasis
GO:1902476 chloride transmembrane transport
GO:0006811 ion transport

Molecular Function

GO:0015379 potassium:chloride symporter activity

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.