Calcium-transporting ATPase type 2C member 1 (IPR030336)

Short name: ATP2C1

Overlapping homologous superfamilies

Family relationships


ATP2C1 (also known as SPCA1) belongs to the IIA subfamily of P-type ATPases family, whose members are Ca2+ ATPases that catalyse the hydrolysis of ATP coupled with the transport of calcium across the membrane. ATP2C1 is a secretory pathway Ca-ATPase that shares significant homology to the yeast ATPase Pmr1, which is responsible for transporting calcium and manganese ions into the Golgi apparatus [PMID: 17603109, PMID: 22240025].

ATP2C1 is linked to the F-actin through cofilin, and this interaction promotes Ca2+-mediated secretory cargo sorting [PMID: 25179631]. Mutations in ATP2C1 cause Hailey-Hailey disease (HHD), which is characterised by persistent blisters and erosions of the skin, due to impaired keratinocyte adhesion [PMID: 10615129, PMID: 10767338, PMID: 11841554, PMID: 11874499].

GO terms

Biological Process

GO:0070588 calcium ion transmembrane transport

Molecular Function

GO:0005524 ATP binding
GO:0005388 calcium-transporting ATPase activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.