Calcium-transporting ATPase type 2C member 2 (IPR030334)

Short name: ATP2C2

Overlapping homologous superfamilies

Family relationships


Secretory pathway Ca-ATPase 2 (SPCA2), also known as ATP2C2, belongs to the IIA subfamily of P-type ATPases, whose members are Ca2+ ATPases that catalyse the hydrolysis of ATP coupled with the transport of calcium across the membrane [PMID: 22240025].

In mammals, SPCA2 plays a role in lactation [PMID: 18334228]. Its expression is linked to tumorigenesis in mammary tumours [PMID: 20887894]. Mutations in the SPCA2 gene are linked to speech and language disorders [PMID: 20955937].

GO terms

Biological Process

GO:0070588 calcium ion transmembrane transport

Molecular Function

GO:0005524 ATP binding
GO:0005388 calcium-transporting ATPase activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.