Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (IPR030330)

Short name: SERCA3

Overlapping homologous superfamilies

Family relationships


SERCA3 belongs to the IIA subfamily of P-type ATPases, whose members are Ca2+ ATPases that catalyse the hydrolysis of ATP coupled with the transport of calcium across the membrane. SERCA3 is a specialised Ca2+ pump, known as SERCA pump, which is localised in sarcoplasmic reticulum and endoplasmic reticulum [PMID: 17286271]. This entry also includes SERCA3 homologues from insects and plants. In plants, the enzyme also has a role in manganese nutrition [PMID: 18024560].

There are several alternatively spliced SERCA3 isoforms in humans that are involved in maintaining normal heart function [PMID: 19962989]. In cancer cells, SERCA3 is involved in cell differentiation and tumorigenesis [PMID: 23157274]. Mutations in the human SERCA3 gene are also associated with type 2 diabetes [PMID: 21885870].

GO terms

Biological Process

GO:0070588 calcium ion transmembrane transport

Molecular Function

GO:0005524 ATP binding
GO:0005388 calcium-transporting ATPase activity

Cellular Component

GO:0005783 endoplasmic reticulum
GO:0016021 integral component of membrane
GO:0033017 sarcoplasmic reticulum membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.