Family

Solute carrier family 26 member 7 (IPR030329)

Short name: SLC26A7

Family relationships

Description

Solute carrier family 26 member 7 (SLC26A7) acts as a sodium-independent DIDS (4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid)-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport [PMID: 12965893, PMID: 17404755, PMID: 16263805]. SLC26A7 has been reported to exhibit the Cl-/HCO3- exchange activity [PMID: 15284286] and the pH-regulated Cl- channel activity with minimal OH-/HCO3- permeability [PMID: 15591059]. Mouse SLC26A7 is localised in the basolateral membrane of gastric parietal cells and of Alpha intercalated cells (A-IC) in outer medullary collecting duct [PMID: 17404755, PMID: 15284286]. Deletion of SLC26A7 in mice causes distal renal tubular acidosis and impaired gastric acid secretion [PMID: 19723628].

Note: DIDS is a stilbene sulfonate that can be used to inhibit anionic transport.

GO terms

Biological Process

GO:0006820 anion transport
GO:0001696 gastric acid secretion

Molecular Function

GO:0008509 anion transmembrane transporter activity

Cellular Component

GO:0016323 basolateral plasma membrane
GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER