Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (IPR030327)

Short name: SERCA2

Family relationships


SERCA2 belongs to the IIA subfamily of P-type ATPases, whose members are Ca2+ ATPases that catalyse the hydrolysis of ATP coupled with the transport of calcium across the membrane. SERCA2 is a specialised Ca2+ pump, known as SERCA pump, which is localised in sarcoplasmic reticulum and endoplasmic reticulum [PMID: 17286271].

Mutations in the SERCA2 gene cause Darier disease, which is characterised by loss of adhesion between suprabasal epidermal keratinocytes (acantholysis) and abnormal keratinization (dyskeratosis) [PMID: 20423818]. There are several alternatively spliced SERCA2 isoforms in humans that are involved in maintaining normal heart function [PMID: 19962989].

GO terms

Biological Process

GO:0070588 calcium ion transmembrane transport

Molecular Function

GO:0005524 ATP binding
GO:0005388 calcium-transporting ATPase activity

Cellular Component

GO:0005783 endoplasmic reticulum
GO:0016021 integral component of membrane
GO:0033017 sarcoplasmic reticulum membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.