Solute carrier family 26 member 3 (DRA) (IPR030321)

Short name: SLC26A3

Overlapping homologous superfamilies


Family relationships


SLC26A3 or DRA (Down Regulated in Adenoma) is a member of the solute carrier family 26 (SLC26) that plays a major role in mediating Cl- absorption in the intestine. DRA absorbs Cl- and exports HCO3- in the small intestine in a partly carbonic anhydrase II-dependent fashion [PMID: 24233434]. DRA also contributes to sulfate secretion [PMID: 23660504]. Deletion of DRA results in reduced colonic HCO3- secretion, loss of colonic fluid absorption, and a lack of adherent mucus layer [PMID: 24373192]. Mutations in DRA cause congenital chloride diarrhea, characterised by chronic secretory diarrhea containing an excess of chloride [PMID: 21394828].

DRA is also involved in sperm capacitation [PMID: 21976599, PMID: 24115633].

GO terms

Biological Process

GO:0015701 bicarbonate transport
GO:0006821 chloride transport

Molecular Function

GO:0015301 anion:anion antiporter activity

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.