Potassium-transporting ATPase alpha chain 2 (IPR030318)

Short name: Atp12a

Overlapping homologous superfamilies

Family relationships


Potassium-transporting ATPase alpha chain 2 (Atp12a) is a non-gastric H,K-ATPase that functions as an H+,NH4(+)-ATPase [PMID: 16046397]. It belongs to the small IIC subfamily of P-type ATPases, whose members function with a beta-subunit to transport K+ into the cell in exchange for either Na+ or H+ [PMID: 17137554]. Instead of having its own beta-subunit, Atp12a uses the beta1-subunit of Na,K-ATPase [PMID: 17137554]. In humans, it is localised in distal kidney and may be involved in H(+)/Na(+) and/or H(+)/NH(4)(+) transport [PMID: 17137554].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005524 ATP binding
GO:0019829 cation-transporting ATPase activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.