Family

Fatty acid transport protein 4 (IPR030304)

Short name: FATP4

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Fatty acid transport protein 4 (FATP4; also known as very long-chain acyl-CoA synthetase 4, ACSVL4) belongs to the FATP family, whose members facilitate long- and very long-chain fatty acid uptake [PMID: 23271751, PMID: 15469937]. It exhibits acyl-CoA synthetase activity and has been proposed to facilitate uptake of fatty acids indirectly by mediating their esterification to CoA [PMID: 11404000]. Mutations in FATP4 cause ichthyosis prematurity syndrome (IPS), characterised by premature birth, respiratory distress, and edematous skin with severe ichthyotic scaling [PMID: 25184958].

GO terms

Biological Process

GO:0015908 fatty acid transport

Molecular Function

GO:0004467 long-chain fatty acid-CoA ligase activity
GO:0031957 very long-chain fatty acid-CoA ligase activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
PANTHER