Fatty acid transport protein 5 (IPR030302)

Short name: FATP5

Overlapping homologous superfamilies


Family relationships



Fatty acid transport protein 5 (FATP5; also known as bile acyl-CoA synthetase) belongs to the FATP family, whose members facilitate long- and very long-chain fatty acid uptake [PMID: 23271751, PMID: 15469937]. FATP5 is a bifunctional protein required for both hepatic fatty acid uptake and bile acid reconjugation [PMID: 17495600]. It has bile acid-CoA ligase activity. Fatp5 knockout mice exhibit lower levels of hepatic triglycerides and free fatty acids due to decreased liver fatty acid uptake [PMID: 18524776].

GO terms

Biological Process

GO:0006699 bile acid biosynthetic process

Molecular Function

GO:0015245 fatty acid transmembrane transporter activity
GO:0004467 long-chain fatty acid-CoA ligase activity
GO:0031957 very long-chain fatty acid-CoA ligase activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.