Ubiquitin thioesterase OTUB1 (IPR030298)

Short name: OTUB1

Overlapping homologous superfamilies


Family relationships


OTUB1 (also known as otubain-1) is a deubiquitinating enzyme that belongs to the OTU family of cysteine proteases [PMID: 23955022]. OTUB1 can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation [PMID: 12704427]. It also plays a key non-catalytic role in DNA repair regulation by inhibiting activity of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites [PMID: 20725033, PMID: 20725029]. Mutations in OTUB1 cause tumour predisposition syndrome (TPDS), characterised by predisposition to develop a variety of tumours [PMID: 21874000].

GO terms

Biological Process

GO:0016579 protein deubiquitination

Molecular Function

GO:0004843 thiol-dependent ubiquitin-specific protease activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.