Ubiquitin carboxyl-terminal hydrolase L1 (IPR030297)

Short name: UCHL1

Overlapping homologous superfamilies

Family relationships



Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is a deubiquitinase that has dual hydrolase and ligase activities [PMID: 23695785]. It is the most abundant protein in brain lysates (1-2%), regulating the timing and the pattern of ubiquitination [PMID: 23695785]. Mutations in the UCHL1 gene has been linked to neurodegenerative diseases [PMID: 20949132, PMID: 17586089]. UCHL1 also pays a major role in oncogenesis [PMID: 23695785].

GO terms

Biological Process

GO:0016579 protein deubiquitination

Molecular Function

GO:0016787 hydrolase activity
GO:0016874 ligase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.