Family

Palmitoyl-protein thioesterase 1 (IPR030294)

Short name: PPT1

Family relationships

Description

Palmitoyl-protein thioesterase 1 (PPT1) is responsible for the removal of a palmitate group from its substrate proteins, which may include presynaptic proteins like SNAP-25, cysteine string protein (CSP), dynamin, and synaptotagmin [PMID: 24091420]. Mutations in the PPT1 gene cause infantile-onset neuronal ceroid lipofuscinosis (INCL), which is a severe pediatric neurodegenerative disorder [PMID: 23747979]. This entry also includes uncharacterised proteins from fungi and plants.

GO terms

Biological Process

GO:0002084 protein depalmitoylation

Molecular Function

GO:0008474 palmitoyl-(protein) hydrolase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER