Voltage-dependent anion-selective channel protein 3 (IPR030271)

Short name: VDAC3

Overlapping homologous superfamilies

Family relationships


This entry includes VDAC3 from vertebrates and DmVDAC from fruit flies. Recombinant VDAC3 shows a channel activity with a very small conductance [PMID: 25171321]. VDAC3 is involved in the transport of ADP across the mitochondrial outer membrane in the cardiac muscle (oxidative muscle) but not in the gastrocnemius muscle (mixed muscle) [PMID: 20875390]. VDAC3 is also a centrosomal protein that interacts with the centrosomal protein kinase Mps1 [PMID: 22935710]. VDAC3 and Mps1 negatively regulate ciliogenesis; they promote ciliary disassembly during cell cycle entry and suppress cilia assembly in proliferating cells [PMID: 23388454]. Mice lacking VDAC3 suffered from immotile sperm and infertility [PMID: 11507092].

Voltage dependent anion channels (VDACs) or porins by analogy with bacterial porins, are pore-forming proteins associated with mitochondria, although they are also present in the endoplasmic reticulum (ER) [PMID: 15238267] and plasma membrane [PMID: 20184885]. In mammals, three VDAC isoforms have been identified: VDAC1 to 3. They have a very similar predicted structure, consisting of a 19 amphipathic beta-strands barrel with an N-terminal alpha-helix in the central pore [PMID: 20138821, PMID: 24642864]. The channel opening faces both the cytosol and mitochondrial intermembrane space [PMID: 18755977, PMID: 24908397]. They play a major role in cellular energetic metabolism due to its ability to allow the exchange of molecules between the cytosol and the mitochondrial intermembrane space. They may also play a role in cell death. However, several mouse gene knock out studies show that VDACs are dispensable for both MPT (mitochondrial permeability transition) and Bcl-2 family member-driven cell death [PMID: 25087640, PMID: 17417626].

GO terms

Biological Process

GO:1902017 regulation of cilium assembly

Molecular Function

GO:0008308 voltage-gated anion channel activity

Cellular Component

GO:0005739 mitochondrion

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.