Voltage-dependent anion-selective channel protein 1 (IPR030270)

Short name: VDAC1

Overlapping homologous superfamilies

Family relationships


VDAC-1 (outer mitochondrial membrane protein porin 1) is a voltage dependent anion channel that mediates the flow of metabolites and ions across the outer mitochondrial membrane. VDAC-1 appeares to be a pro-apoptotic protein through oligomerisation [PMID: 25087640]. It is implicated in cell death induction for its ability to interact with BAX, a protein belonging to the BCL-2 protein family. BAX plays a role in apoptosis and mitochondrial function regulation via multiple protein-protein interactions with BCL-2, BAK, BID or other members of the family [PMID: 11259441, PMID: 17209561].

Voltage dependent anion channels (VDACs) or porins by analogy with bacterial porins, are pore-forming proteins associated with mitochondria, although they are also present in the endoplasmic reticulum (ER) [PMID: 15238267] and plasma membrane [PMID: 20184885]. In mammals, three VDAC isoforms have been identified: VDAC1 to 3. They have a very similar predicted structure, consisting of a 19 amphipathic beta-strands barrel with an N-terminal alpha-helix in the central pore [PMID: 20138821, PMID: 24642864]. The channel opening faces both the cytosol and mitochondrial intermembrane space [PMID: 18755977, PMID: 24908397]. They play a major role in cellular energetic metabolism due to its ability to allow the exchange of molecules between the cytosol and the mitochondrial intermembrane space. They may also play a role in cell death. However, several mouse gene knock out studies show that VDACs are dispensable for both MPT (mitochondrial permeability transition) and Bcl-2 family member-driven cell death [PMID: 25087640, PMID: 17417626].

GO terms

Biological Process

GO:0006820 anion transport

Molecular Function

GO:0008308 voltage-gated anion channel activity

Cellular Component

GO:0016021 integral component of membrane
GO:0005741 mitochondrial outer membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.