Nesprin-4 (IPR030268)

Short name: SYNE4

Overlapping homologous superfamilies


Family relationships



Nesprins (nuclear envelope spectrin-repeat proteins) are a family of giant spectrin-repeat containing proteins that act as versatile intracellular protein scaffolds [PMID: 22768332]. They are characterised by a central extended spectrin-repeat (SR) and a C-terminal Klarsicht/ANC-1/Syne homology (KASH) domain that can associate with Sad1p/UNC-84 (SUN)-domain proteins of the inner nuclear membrane within the periplasmic space of the nuclear envelope (NE) [PMID: 17158909].

This entry represents Nesprin-4 from mammals. Nesprin-4 links the nucleus to microtubules through its binding to kinesin-1 [PMID: 19164528]. It is a component of the linker of the nucleoskeleton and cytoskeleton (LINC) complex, which plays critical roles in nuclear positioning, cell polarisation and cellular stiffness [PMID: 22945352].

This entry also conbtains the karyogamy meiotic segregation protein 2 (kms2) from the fission yeast Schizosaccharomyces pombe. Kms2 contains a KASH domain and during interphase colocalizes within the nuclear envelope with the SUN domain-containing protein Sad1 at the site of attachment of the spindle pole body (SPB, the yeast version of the centrosome). Kms2 interacts with the SPB components Cut12 and Pcp1 and the Polo kinase Plo1 and is important for remodelling of the SPB and entry of the cell into mitosis [PMID: 24963130].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0034993 meiotic nuclear membrane microtubule tethering complex
GO:0005635 nuclear envelope

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.