Nesprin-3 (IPR030267)

Short name: SYNE3

Overlapping homologous superfamilies


Family relationships



Nesprin-3 links the nucleus to the intermediate filaments through the binding to the cytoskeletal linker protein plectin [PMID: 16330710]. It is a component of the linker of the nucleoskeleton and cytoskeleton (LINC) complex, which plays critical roles in nuclear positioning, cell polarisation and cellular stiffness [PMID: 22945352]. Nesprin-3 can also connect the nucleus to microtubules by its interactions with BPAG1 (bullous pemphigoid antigen 1) and MACF (microtubule-actin cross-linking factor) [PMID: 22103514].

Nesprin-3 contains a conserved Klarsicht/ANC-1/Syne homology (KASH) domain at its C terminus that can associate with Sad1p/UNC-84 (SUN)-domain proteins of the inner nuclear membrane within the periplasmic space of the nuclear envelope (NE) [PMID: 17158909]. It also has a plectin-binding motif that permits interactions with cytoplasmic intermediate filaments [PMID: 21177090].

GO terms

Biological Process

GO:0090286 cytoskeletal anchoring at nuclear membrane

Molecular Function

GO:0008092 cytoskeletal protein binding

Cellular Component

GO:0005640 nuclear outer membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.