Nesprin-1 (IPR030265)

Short name: SYNE1

Overlapping homologous superfamilies


Family relationships



Nesprins (nuclear envelope spectrin-repeat proteins) are a family of giant spectrin-repeat containing proteins that act as versatile intracellular protein scaffolds [PMID: 22768332]. They are characterised by a central extended spectrin-repeat (SR) and a C-terminal Klarsicht/ANC-1/Syne homology (KASH) domain that can associate with Sad1p/UNC-84 (SUN)-domain proteins of the inner nuclear membrane within the periplasmic space of the nuclear envelope (NE) [PMID: 17158909]. Nesprin-1 and nesprin-2 also contain an N-terminal calponin homology (CH) domain that links to filamentous actin (F-actin) [PMID: 21177090]. Full length Nesprin-1 and nesprin-2 are large multidomain proteins. Smaller N-terminally truncated isoforms lacking the CH domains localise to the inner nuclear membrane, while isoforms that lack the KASH domain have been shown to localise to other regions of cells, including focal adhesions [PMID: 22768332].

This entry represents nesprin-1 from animals, including insects and vertebrates. Nesprin-1 and nesprin-2 are key components of the linker of the nucleoskeleton and cytoskeleton (LINC) complex, which plays critical roles in nuclear positioning, cell polarisation and cellular stiffness [PMID: 22945352]. They also regulate endothelial cell shape and migration [PMID: 24931616]. Nesprin-1 also plays a role in DNA damage response [PMID: 24781983].

GO terms

Biological Process

GO:0090286 cytoskeletal anchoring at nuclear membrane

Molecular Function

GO:0051015 actin filament binding

Cellular Component

GO:0034993 meiotic nuclear membrane microtubule tethering complex
GO:0005635 nuclear envelope

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.