Chloride intracellular channel protein 1 (IPR030259)

Short name: CLIC-1

Overlapping homologous superfamilies

Family relationships


Intracellular chloride ion channel proteins (CLICs) has been shown to exist in both soluble and integral membrane forms. Chloride intracellular channel protein 1 (CLIC1) can insert into membranes and form chloride ion channels [PMID: 11940526]. Membrane insertion seems to be redox-regulated and may occur only under oxydising conditions [PMID: 14613939]. Channel activity has been shown to have a strong pH dependence [PMID: 11978800]. The soluble form of CLIC1 is monomeric and structurally homologous to the glutathione S-transferase superfamily, with a redox-active site resembling glutaredoxin [PMID: 11551966].

CLIC-1 (also known as NCC27) is involved in regulation of the cell cycle [PMID: 11195932].

GO terms

Biological Process

GO:0006821 chloride transport
GO:0051726 regulation of cell cycle

Molecular Function

GO:0005254 chloride channel activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.