Chloride intracellular channel protein 4 (IPR030257)

Short name: CLIC-4

Overlapping homologous superfamilies

Family relationships


Like several other chloride intracellular channel (CLIC) proteins, CLIC4 is dimorphic and can exist in soluble form or as a membrane channel. It has a transmembrane domain and is found in intracellular membranes including inner mitochondrial membrane, trans Golgi network and the endoplasmic reticulum. It has putative chloride ion selective channel activity [PMID: 9295337]. Soluble CLIC4 is abundant in the cytoplasm and can translocate to the nucleus under conditions of metabolic stress, apoptosis and DNA damage [PMID: 14610078]. CLIC4 is upregulated in response to p53 transcriptional activity and is essential for p53 and c-Myc mediated apoptosis [PMID: 10593946, PMID: 16316993].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.