Family

ATP-binding cassette subfamily G member 2 (IPR030256)

Short name: ABCG2

Family relationships

None.

Description

ATP-binding cassette subfamily G member 2 (ABCG2) is a eukaryotic member of the ABC transporter family. In humans, ABCG2 is a high-capacity urate exporter, functioning in both renal and extrarenal urate excretion [PMID: 22132962]. It is a major factor contributing to gout [PMID: 22132963, PMID: 22132966]. It also coordinates with another transporter, ABCB6, to modulate porphyrin concentrations under normal physiological and pathological conditions [PMID: 21118089]. In addition, it can function as a xenobiotic transporter and may play a major role in multi-drug resistance [PMID: 25162314].

The ABC transporter family is a group of membrane proteins that use the hydrolysis of ATP to power the translocation of a wide variety of substrates across cellular membranes. ABC transporters minimally consist of two conserved regions: a highly conserved nucleotide-binding domain (NBD) and a less conserved transmembrane domain (TMD). Eukaryotic ABC proteins are usually organised either as full transporters (containing two NBDs and two TMDs), or as half transporters (containing one NBD and one TMD), that have to form homo- or heterodimers in order to constitute a functional protein [PMID: 11441126].

GO terms

Biological Process

GO:0055085 transmembrane transport

Molecular Function

GO:0005524 ATP binding
GO:0042626 ATPase activity, coupled to transmembrane movement of substances

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER