Chloride intracellular channel protein 2 (IPR030253)

Short name: CLIC-2

Overlapping homologous superfamilies

Family relationships


Chloride intracellular channel (CLIC) proteins are multifunctional and participate in a wide variety of signaling activities. CLIC proteins are able to convert from a water-soluble state to a membrane channel state [PMID: 12202911]. Chloride intracellular channel protein 2 (CLIC-2) is found in several tissues, including skeletal muscle and myocardium. It inhibits cardiac ryanodine receptor Ca2+ release channels [PMID: 15147738, PMID: 15916532].

GO terms

Biological Process

GO:1902476 chloride transmembrane transport
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity

Molecular Function

GO:0005254 chloride channel activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.