SLIT-ROBO Rho GTPase-activating protein 2 (IPR030252)

Short name: srGAP2

Overlapping homologous superfamilies


Family relationships



The SLIT-ROBO Rho GTPase-activating protein (srGAP) family consists of four members: srGAP1, -2, -3 and -4. They contain F-BAR, RhoGAP and SH3 domains. Their RhoGAP domain is involved in negative regulation of Rho GTPase activities important for cytoskeleton rearrangement [PMID: 20810653]. The srGAP family members have an "inverse F-BAR" or IF-BAR domain that is distinct from other F-BAR domains such as FBP17. They are multifunctional adaptor proteins involved in various aspects of neuronal development [PMID: 23505444].

srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells [PMID: 23505444]. This entry also includes human srGAP2 duplication gene, SLIT-ROBO Rho GTPase-activating protein 2B and 2C (srGAP2B/C) [PMID: 28333212]. srGAP2C encodes a truncated F-BAR domain protein that dimerises with srGAP2 to inhibit its function and thruogh this interaction with srGAP2 is involved in dendritic spine maturation [PMID: 22559944].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.