Sodium/potassium/calcium exchanger 3 (IPR030248)

Short name: SLC24A3

Overlapping homologous superfamilies


Family relationships


Potassium-dependent sodium/calcium exchanger 3 (NCKX3), also known as SLC24A3, functions in the transport of intracellular calcium across the cell membrane in exchange for extracellular sodium ions. NCKX3 is expressed in brain, aorta, uterus, and intestine, all of which are rich in smooth muscle cells [PMID: 11294880]. NCKX3 is regulated by the steroid hormones estrogen and progesterone and might be involved in reproductive function during the estrous cycle [PMID: 19464262, PMID: 21321244].

GO terms

Biological Process

GO:0006811 ion transport

Molecular Function

GO:0008273 calcium, potassium:sodium antiporter activity

Cellular Component

GO:0005886 plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.