Canalicular multispecific organic anion transporter 1 (IPR030247)
Short name: ABCC2
Overlapping homologous superfamilies
- Multi drug resistance-associated protein (IPR005292)
- Canalicular multispecific organic anion transporter 1 (IPR030247)
This entry represents canalicular multispecific organic anion transporter 1 (also known as MRP2 or ABCC2) from animals. It belongs to the MRP (multidrug resistance protein) subfamily of the ATP-binding cassette (ABC) transporter family [PMID: 21103974]. MRP2 can transport many different substrates, including sulfate, glucuronide, and glutathione conjugates [PMID: 21740521]. It is also responsible for the biliary elimination of certain endogenous conjugates, such as LTC4 and conjugated bilirubins. It plays a role in eliminating endogenous metabolites, as well as xenobiotics and their metabolites [PMID: 21740521].
Mutations in MRP2/ABCC2 cause conjugated hyperbilirubinemia (Dubin-Johnson syndrome), which is an inherited autosomal recessive disorder characterised by chronic conjugated hyperbilirubinemia, impaired secretion of anionic conjugates from hepatocytes into the bile, and deposition of brown pigments in the liver [PMID: 21740521].
The ABC transporter family is a group of membrane proteins that use the hydrolysis of ATP to power the translocation of a wide variety of substrates across cellular membranes. ABC transporters minimally consist of two conserved regions: a highly conserved nucleotide-binding domain (NBD) and a less conserved transmembrane domain (TMD). Eukaryotic ABC proteins are usually organised either as full transporters (containing two NBDs and two TMDs), or as half transporters (containing one NBD and one TMD), that have to form homo- or heterodimers in order to constitute a functional protein [PMID: 11441126].
- PTHR24223:SF176 (PTHR24223:SF176)