Family

Canalicular multispecific organic anion transporter 1 (IPR030247)

Short name: ABCC2

Overlapping homologous superfamilies

None.

Family relationships

Description

This entry represents canalicular multispecific organic anion transporter 1 (also known as MRP2 or ABCC2) from animals. It belongs to the MRP (multidrug resistance protein) subfamily of the ATP-binding cassette (ABC) transporter family [PMID: 21103974]. MRP2 can transport many different substrates, including sulfate, glucuronide, and glutathione conjugates [PMID: 21740521]. It is also responsible for the biliary elimination of certain endogenous conjugates, such as LTC4 and conjugated bilirubins. It plays a role in eliminating endogenous metabolites, as well as xenobiotics and their metabolites [PMID: 21740521].

Mutations in MRP2/ABCC2 cause conjugated hyperbilirubinemia (Dubin-Johnson syndrome), which is an inherited autosomal recessive disorder characterised by chronic conjugated hyperbilirubinemia, impaired secretion of anionic conjugates from hepatocytes into the bile, and deposition of brown pigments in the liver [PMID: 21740521].

The ABC transporter family is a group of membrane proteins that use the hydrolysis of ATP to power the translocation of a wide variety of substrates across cellular membranes. ABC transporters minimally consist of two conserved regions: a highly conserved nucleotide-binding domain (NBD) and a less conserved transmembrane domain (TMD). Eukaryotic ABC proteins are usually organised either as full transporters (containing two NBDs and two TMDs), or as half transporters (containing one NBD and one TMD), that have to form homo- or heterodimers in order to constitute a functional protein [PMID: 11441126].

GO terms

Biological Process

GO:0055085 transmembrane transport

Molecular Function

GO:0042626 ATPase activity, coupled to transmembrane movement of substances
GO:0008514 organic anion transmembrane transporter activity

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER