Canalicular multispecific organic anion transporter 2 (IPR030242)

Short name: ABCC3

Family relationships


This entry represents canalicular multispecific organic anion transporter 2 (also known as MRP3 or ABCC3) from mammals. It belongs to the MRP (multidrug resistance protein) subfamily of the ATP-binding cassette (ABC) transporter family [PMID: 21103974]. MRP3 is a low-affinity glutathione and glucuronate conjugate transporter and has the facility for transporting glycocholate (a major constituent of human bile) [PMID: 10987286].

An elevation in the levels of MRP3 expression has been detected in human cancers [PMID: 21740521, PMID: 11745434].

The ABC transporter family is a group of membrane proteins that use the hydrolysis of ATP to power the translocation of a wide variety of substrates across cellular membranes. ABC transporters minimally consist of two conserved regions: a highly conserved nucleotide-binding domain (NBD) and a less conserved transmembrane domain (TMD). Eukaryotic ABC proteins are usually organised either as full transporters (containing two NBDs and two TMDs), or as half transporters (containing one NBD and one TMD), that have to form homo- or heterodimers in order to constitute a functional protein [PMID: 11441126].

GO terms

Biological Process

GO:0055085 transmembrane transport

Molecular Function

GO:0005524 ATP binding
GO:0042626 ATPase activity, coupled to transmembrane movement of substances

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.