Family

Multidrug resistance-associated protein 5 (IPR030238)

Short name: ABCC5

Family relationships

None.

Description

This entry represents the multidrug resistance-associated protein 5 (MRP5 or ABCC5) from vertebrates. It belongs to the MRP (multidrug resistance protein) subfamily of the ATP-binding cassette (ABC) transporter family [PMID: 21103974]. It is a cyclic nucleotide organic anion transporter, mediating the efflux of a variety of organic anions, including certain monophosphate nucleotide metabolites such as cGMP and cAMP, and certain purine analogues [PMID: 21740521, PMID: 10840050]. MRP5 acts as a selective transporter of cGMP in pituitary cells [PMID: 16614078].

MRP5 is elevated in lung, colon, pancreatic and breast cancer samples and also in the heart following ischemic episodes [PMID: 21740521]. MRP5 could confer resistance to several anticancer drugs, including cisplatin, purine analogues (such as 6-mercaptopurine and 6-thioguanine), pyrimidine analogues (such as gemcitabine, cytosine arabinoside (Ara-C) and 5-fluorouracil (5-FU)) , the natural product doxorubicin and to anti-folate drugs (such as MTX), but not to Vinca alkaloids (such as vincristine) [PMID: 21740521].

GO terms

Biological Process

GO:0015711 organic anion transport

Molecular Function

GO:0005524 ATP binding
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
GO:0008514 organic anion transmembrane transporter activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER